منابع مشابه
Solid phase synthesis of selectively deuterated arenes.
A novel access to deuterated and D(3)CO-substituted arenes has been developed using immobilized triazenes as precursors. The linker system and the deuterating cleavage methodology could be shown to be compatible with various functional groups and are therefore suitable for the synthesis of derivatives only hardly available via comparable protocols.
متن کاملSynthesis of highly deuterated amino acids.
Since the discovery of deuterium,' there has been considerable interest in the preparation of a variety of compounds in which hydrogen has been replaced by this heavier isotope. Some of the research has centered around the synthesis of deuterated compounds for biological study.2 While not occupying a place of prominence in this work, the preparation of deuterated amino acids has been studied in...
متن کاملHuman Cholesterol Synthesis Measurement Using Deuterated Water
Human cholesterogenesis is measurable as the rate of Incorporation of deuterium derived from deuterium oxide (D2O) within the body water pool into plasma or erythrocyte cholesterol pools. Oral D2O equilibrates across body water, thus enabling extracellular sampling of pools (such as urine) to serve as accurate indicators of intracellular deuterium enrichments at the point of synthesis. Required...
متن کاملSynthesis of Antimicrobial N-Phthaloyl-alanyl-derived Amidophosphates and Triazoles
N-Phthaloyl-alanylazide reacts smoothly with trialkyl phosphites producing the corresponding αaminophosphates. With dialkyl hydrogenphosphonates in the presence of benzoyl peroxide, amidophosphates were the isolated products whereas the oxoaziridin-1-yl-phosphonic diamide was preferentially provided from the reaction of the azide with tris(dimethylamino)phosphine. The azide was also allowed to ...
متن کامل"Flash" solvent-free synthesis of triazoles using a supported catalyst.
A solvent-free synthesis of 1,4-disubstituted-1,2,3-triazoles using neat azides and alkynes and a copper(I) polymer supported catalyst (Amberlyst) A21*CuI) is presented herein. As it provides the products in high yields and purities within minutes, this method thus being characterized as a "flash" synthesis, and was exemplified through the synthesis of a 24-compound library on a small scale.
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ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2012
ISSN: 0022-3263,1520-6904
DOI: 10.1021/jo301146j